|
Sick Sinus Syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Loss of Trx2 reduces HCN4 expression via a mitochondrial ROS-HDAC4-MEF2C pathway and subsequently induces sick sinus syndrome in mice.
|
31751569 |
2020 |
|
Chromosome 2q37 deletion syndrome
|
0.680 |
Biomarker
|
disease |
BEFREE |
Genotype and phenotype correlation in 103 individuals with 2q37 deletion syndrome reveals incomplete penetrance and supports HDAC4 as the primary genetic contributor.
|
30848064 |
2019 |
|
Malignant neoplasm of urinary bladder
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
We also observed increased expression in Hdac4, -7, and -9 in commonly used BC mouse models.
|
31137849 |
2019 |
|
Bladder Neoplasm
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
We also observed increased expression in Hdac4, -7, and -9 in commonly used BC mouse models.
|
31137849 |
2019 |
|
Diabetic Nephropathy
|
0.220 |
Biomarker
|
disease |
BEFREE |
The successful in vitro and in vivo delivery of siRNA, as well as targeted gene knockdown potential, was demonstrated by HDAC4 inhibition in vitro diabetic nephropathy (DN) podocyte model as well as in vivo DN C57BL/6 mice model.
|
31690769 |
2019 |
|
Seizures
|
0.110 |
Biomarker
|
phenotype |
BEFREE |
After injection of si-HDAC4, the epilepsy rats presented with a reduction in seizure degree, latency and duration of seizure, amount of scattered epileptic waves, and occurrence of epilepsy, with an improvement in their cognitive function.
|
30787615 |
2019 |
|
Malignant Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Class I histone deacetylases (HDACs) generally promote cell proliferation and tumorigenesis, whereas class IIA HDACs like HDAC4 and HDAC5 may promote or impede cancer development in a tissue-dependent manner.
|
31052182 |
2019 |
|
Neoplasms
|
0.070 |
AlteredExpression
|
group |
BEFREE |
At a functional level, HDAC4 inhibition favored cisplatin cytotoxicity and reduced tumor growth.
|
31703394 |
2019 |
|
Primary malignant neoplasm
|
0.060 |
Biomarker
|
group |
BEFREE |
Class I histone deacetylases (HDACs) generally promote cell proliferation and tumorigenesis, whereas class IIA HDACs like HDAC4 and HDAC5 may promote or impede cancer development in a tissue-dependent manner.
|
31052182 |
2019 |
|
Huntington Disease
|
0.050 |
Biomarker
|
disease |
BEFREE |
To validate and distinguish interactions specifically enhanced in an HD-vulnerable brain region, we next characterized endogenous Hdac4 interactions in dissected striata from this HD mouse series.
|
31040226 |
2019 |
|
Degenerative polyarthritis
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
The effect of HDAC4 upregulation on cartilage damage in OA remains unknown.
|
31310910 |
2019 |
|
Degenerative polyarthritis
|
0.050 |
Biomarker
|
disease |
BEFREE |
Our findings revealed a novel mTORC1-HDAC4-miR-483-5p pathway that is critical for OA development.
|
30145794 |
2019 |
|
Glioma
|
0.040 |
Biomarker
|
disease |
BEFREE |
HDAC class IIa enzymes (HDAC4, 5, 7, 9) are important for glioma progression, invasion, responses to TMZ and radiotherapy, and prognosis.
|
30837601 |
2019 |
|
Glioma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Interestingly, HDAC4 is highly expressed in glioma tissues, and the rate of HDAC4 nuclear import is closely correlated with glioma grade, as well as with MKK7 expression.
|
30963560 |
2019 |
|
Tumor Cell Invasion
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
This research aimed to study the expression of HDAC4 and PCNA and their relation to cell proliferation and invasion in human OS.
|
31552187 |
2019 |
|
Liver carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Still, there was a strong correlation in the expression of HDAC class IIa (HDAC4, 5, 7, 9) as well as HDAC2 and 8 (class I) and HDAC10 (class IIb) and HDAC11 (class IV) in HCC tissues of individual patients.
|
31635225 |
2019 |
|
Heart failure
|
0.030 |
Biomarker
|
disease |
BEFREE |
HDAC4-knockout mice develop heart failure in models of type 1 and type 2 diabetes mellitus, whereas wild-type mice do not develop clear signs of heart failure, indicating that HDAC4 protects the diabetic heart.
|
31195810 |
2019 |
|
Multiple Myeloma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
In addition, TUG1 positively modulated histone deacetylases 4 (HDAC4, a target of miR-29b-3p) expression through sponging of miR-29b-3p in MM cells.<b>Conclusion</b>: These findings suggested that TUG1 exerted an oncogenic role in MM by acting as a competing endogenous RNA of miR-29b-3p, and implied the potential application of TUG1 in treatment for MM.
|
30842339 |
2019 |
|
Osteoporosis
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
MiRNA-19a-3p promotes the osteogenic differentiation of hMSCs by inhibiting HDAC4 expression, thus alleviating the progression of osteoporosis.
|
31248594 |
2019 |
|
Osteosarcoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
<b>Results:</b> The results showed that both HDAC4 and PCNA were increased in human OS tissues.
|
31552187 |
2019 |
|
Abnormal behavior
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
Histone Deacetylase 4 Downregulation Elicits Post-Traumatic Psychiatric Disorders through Impairment of Neurogenesis.
|
31169064 |
2019 |
|
Osteosarcoma of bone
|
0.030 |
Biomarker
|
disease |
BEFREE |
<b>Results:</b> The results showed that both HDAC4 and PCNA were increased in human OS tissues.
|
31552187 |
2019 |
|
Childhood Osteosarcoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
<b>Results:</b> The results showed that both HDAC4 and PCNA were increased in human OS tissues.
|
31552187 |
2019 |
|
Amyotrophic Lateral Sclerosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
HDAC4 plays an important role in preserving innervations and skeletal muscle in ALS, likely by modulating the UCP1 gene network.
|
30713114 |
2019 |
|
Anorexia Nervosa
|
0.020 |
Biomarker
|
disease |
BEFREE |
Despite the fact that HDAC4 has not been identified as a significant signal in genome-wide association studies in AN, several studies have found significant or near-significant methylation differences in HDAC4 locus in peripheral tissues of actively ill AN patients in comparison with different control groups.
|
30742020 |
2019 |